Fatal Cryptococcus gattii genotype AFLP6/VGII infection in a HIV‐negative patient: case report and a literature review |
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| Authors: | Olivia Cometti Favalessa Márcia dos Santos Lázera Bodo Wanke Luciana Trilles Doracilde Terumi Takahara Tomoko Tadano Luciana Basili Dias Ananda Castro Vieira Glaúcia Vanessa Novack Rosane Christine Hahn |
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| Affiliation: | 1. Laboratório de Micologia, Faculdade de Medicina, Universidade Federal de Mato Grosso, , Cuiabá, MT, Brazil;2. IPEC – Laboratório de Micologia, FIOCRUZ, , Rio de Janeiro, RJ, Brazil;3. Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, , Cuiabá, MT, Brazil |
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| Abstract: | Cryptococcus gattii, a species belonging to the Cryptococcus complex which occurs endemically in tropical and subtropical regions, has been reported as a causative agent of cryptococcosis in healthy individuals. We report a case of meningitis in HIV‐negative patient from Cuiaba, MT, in the Midwestern region of Brazil. Cryptococcus gattii AFLP6/VGII was isolated from cerebrospinal fluid and molecular typing was performed by URA5‐RFLP. The in vitro susceptibility profile was determined using the standard method according to the document M27A3, CLSI 2008. C. gattii AFLP6/VGII was shown to be susceptible to the antifungals tested. Treatment with 0.8 mg/kg of amphotericin B was initiated; however, the patient died 2 days after the onset of therapy. |
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| Keywords: | Neurocryptococcosis
Cryptococcus gattii
seronegative for HIV midwestern of Brazil |
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