Induction of phosphorylated c‐Jun in neonatal spinal motoneurons after axonal injury is coincident with both motoneuron death and regeneration |
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| Authors: | Qiuju Yuan Huanxing Su Jiasong Guo Wutian Wu Zhi‐Xiu Lin |
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| Institution: | 1. Faculty of Medicine, School of Chinese Medicine, The Chinese University of Hong Kong, , Hong Kong, China;2. Department of Anatomy, University of Hong Kong, , Hong Kong, China;3. State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, , Macao, China;4. State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, , Pokfulam, Hong Kong, China;5. Li Ka Shing Faculty of Medicine, Research Center of Reproduction, Development and Growth, The University of Hong Kong, , Pokfulam, Hong Kong, China;6. GHM Institute of CNS regeneration, Jinan University, , Guangzhou, China |
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| Abstract: | c‐Jun activation has been implicated not only in neuronal degeneration, but also in survival and regeneration. Here, we investigated c‐Jun activation in injured motoneurons by using a nerve crush model in neonatal rats. We identified two distinct subpopulations of motoneurons: about 60% underwent degeneration following injury whereas the remaining 40% survived and induced a regeneration response at 3 weeks post injury. However, all motoneurons examined expressed phosphorylated‐c‐Jun‐immunoreactivity (p‐c‐Jun‐IR) at the early stage of 3 days following injury. These results suggest that active c‐Jun was induced in all neonatal motoneurons following nerve crush injury, regardless of whether they were destined to degenerate or undergo successful regeneration at a later stage. Our findings therefore support the hypothesis that active c‐Jun is involved in both neuronal degeneration and regeneration. |
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| Keywords: | axonal injury motoneuron Phosphorylated c‐Jun regeneration spinal cord |
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