Long-term results of a prospective randomized trial comparing tacrolimus versus cyclosporine in African– American recipients of primary cadaver renal transplant |
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Authors: | Tomasz Jarzembowski Fabrizio Panaro Vandad Raofi Guanglong Dong Giuliano Testa Howard Sankary Enrico Benedetti |
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Affiliation: | Department of Surgery, Division of Transplantation, University of Illinois at Chicago, 60612, USA. |
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Abstract: | The ideal immunosuppressive treatment for African-American kidney transplant recipients has not been established. We performed a long-term prospective randomized trial comparing the results of tacrolimus (TAC) and cyclosporine (CSA) in the African-American population. Thirty-five African-American primary cadaveric renal transplant (CRT) recipients were enrolled in the study. Group I (n = 14) received TAC and group II (n = 21) received CSA; mean follow up was 78 months. We found no difference in patient/graft survival rates between the groups. Twelve patients in the CSA group were converted to TAC, mostly because of hypercholesterolemia or as a rescue for an acute rejection episode. Significant lower creatinine and cholesterol levels were seen at 1 year post-transplant, but this difference lost significance at 3 and 5 years, possibly because of conversion of most patients from CSA to TAC. In conclusion, African-American recipients of primary CRTs can achieve excellent long-term results with TAC-based immunosuppression. |
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Keywords: | African–Americans cadaveric kidney transplantation tacrolimus |
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