2型糖尿病患者真胰岛素、胰岛素原测定的临床意义

目的 :探讨 2型糖尿病患者体内真胰岛素、胰岛素原的水平及意义。方法 :采用ELISA测定 73例糖尿病患者 (分为单纯糖尿病A组和胰岛素抵抗综合症B组 )和 3 0例健康者对照组 (hormalcontrol,NC)体内的空腹真胰岛素、空腹胰岛素原水平。结果 :糖尿病组的真胰岛素、胰岛素原水平均高于正常组 ,且差异具有显著性 (P <0 0 5 ) ;胰岛素抵抗综合症组的真胰岛素、胰岛素原高于单纯糖尿病组 ,且差异具有显著性(P <0 0 5 )。结论 :2型糖尿病患者空腹真胰岛素、空腹胰岛素原的水平都高于正常对照组 ;胰岛素原 ,它不仅提示胰岛素抵抗 ,还反映胰岛B细胞功能下降。

Explore the levels of proinsulin and true insulin in type 2 diabete mellitus patients

Objective:To explore the levels of proinsulin and true insulin in type 2 diabete mellitus patients.Methods:The levels of fasting proinsulin(FPI) and fasting true insulin (FTI) were detected by ELISA in 30 healthy subjects(NC) and 73 type 2 diabete mellitus patients,who were allocated into two groups,one was simple diabetes mellitus group(A group),the other was insulin resistance syndnme group(B group).Results:The levels of FPI and FTI in diabetes mellitus group were significantly higher than normal control group;the levels of FPI and FTI in B group were significantly higher than A group.Conclusion: The levels of both PI and TI were higher in type 2 diabete mellitus patients than normal control.PI implied not only insulin resistance also B-cell dysfuncation.