| 喉癌p53蛋白和EGFR的免疫组织化学检测及意义 |
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| 引用本文： | 牛晨阳 任玉霞. 喉癌p53蛋白和EGFR的免疫组织化学检测及意义[J]. 临床耳鼻咽喉头颈外科杂志, 1996, 10(3): 137-139 |
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| 作者姓名： | 牛晨阳 任玉霞 |
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| 作者单位： | 解放军第457医院耳鼻咽喉科，解放军第457医院耳鼻咽喉科，解放军第457医院耳鼻咽喉科，解放军第457医院病理科 武汉 430012，武汉 430012，武汉 430012 |
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| 摘 要： | 应用ＬＳＡＢ免疫组织化学染色法，对３２例原发喉鳞状细胞和８例喉正常上皮组织中的ｐ５３蛋白和表皮生长因子受体做定位和定量研究。结果表明：ｐ５３蛋白在喉癌组织中的表达位于细胞核内，ＥＧＦＲ的表达位于胞浆和核膜；喉癌组织中这二种癌基因表达的蛋白阳性率，ｐ５３为５９．４％，ＥＧＦＲ为６８．８％，ＥＧＦＲ在喉癌组织中的阳性率和强度与病理分级和临床预后显著性相关，ｐ５３在喉癌早期病例中表达的阳怀率明显增高。
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| 关 键 词： | 喉肿瘤 p53蛋白 表皮生长因子 受体 |
Examination of p53 protein and EGFR by immunohistochemistry method in human primary laryngeal cancer and their clinical significance |
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| Niu Chenyang Wang Guoxian Ren Zhenlian et al. Examination of p53 protein and EGFR by immunohistochemistry method in human primary laryngeal cancer and their clinical significance[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 1996, 10(3): 137-139 |
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| Authors: | Niu Chenyang Wang Guoxian Ren Zhenlian et al |
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| Abstract: | Thirty two cases of primary laryngeal cancer and eight cases of normal laryngeal tissue specimens were examined to observe the expression of p53 protein and epidermal growth factor receptor(EGFR) with immunohistochemistry method. The results showed that the p53 protein expression was located in the nuclei and the EGFR expression was both located in cytoplasm and nucleal membranes. The positive expressions for p53 and EGFR in laryngeal cancer were 59. 4% and 68. 8% respectively. The EGFR expression was related to the degree of cell differentiation and prognosis. The p53 protein expression in laryngeal cancer was related to T classification. Significantly lower EGFR levels was found in the normal mucosa. p53 protein expression could not be found in normal mucosa. |
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| Keywords: | Laryngeal neoplasms Oncogenes Immunohistochemical staining p53 protein Epidermal grouth factor receptor |
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