| Planar cell polarity genes, Celsr1-3, in neural development |
| |
| 基金项目： | supported by grants from the Program for New Century Excellent Talents in University, Ministry of Education of China (NCET-09-0109);the National Natural Science Foundation of China (31070955);the Doctoral Fund of the Ministry of Education of China (21310045);the Fundamental Research Funds for the Central Universities, Ministry of Education of China (21610604 and 21609101) |
| |
| 摘 要： | flamingo is among the ’core’ planar cell-polarity genes, protein of which belongs to a unique cadherin subfamily. In contrast to the classic cadherins, composed of several extracellular cadherin repeats, one transmembrane domain and one cytoplasmic segment linked to catenin binding, Drosophila Flamingo has seven transmembrane segments and a cytoplasmic tail with no catenin-binding sequence. In Drosophila, Flamingo has pleotropic roles in controlling epithelial polarity and neuronal morphogenesis. Three mammalian orthologs of flamingo, Celsr1-3, are widely expressed in the nervous system. Recent work has shown that Celsr1-3 play important roles in neural development, such as in axon guidance, neuronal migration, and cilium polarity. Celsr1-3 single-gene knockout mice exhibit different phenotypes, but there are cooperative interactions among these genes.
|
| 关 键 词： | planar cell polarity Celsr genes neural development |
| 收稿时间： | 2011 Nov 25 |
Planar cell polarity genes, Celsr1-3, in neural development |
| |
| Authors: | Jia Feng Qi Han Libing Zhou |
| |
| Institution: | The University of Hong Kong, Medical School of Jinan University, Guangzhou 510632, China |
| |
| Abstract: | flamingo is among the ‘core’ planar cell-polarity genes, protein of which belongs to a unique cadherin subfamily. In contrast to the classic cadherins, composed of several extracellular cadherin repeats, one transmembrane domain and one cytoplasmic segment linked to catenin binding, Drosophila Flamingo has seven transmembrane segments and a cytoplasmic tail with no catenin-binding sequence. In Drosophila, Flamingo has pleotropic roles in controlling epithelial polarity and neuronal morphogenesis. Three mammalian orthologs of flamingo, Celsr1–3, are widely expressed in the nervous system. Recent work has shown that Celsr1–3 play important roles in neural development, such as in axon guidance, neuronal migration, and cilium polarity. Celsr1–3 single-gene knockout mice exhibit different phenotypes, but there are cooperative interactions among these genes. |
| |
| Keywords: | planar cell polarity Celsr genes neural development |
| 本文献已被 CNKI SpringerLink 等数据库收录！ |
|
