氯氮平治疗精神分裂症3年随访观察

目的 探讨氯氮平治疗精神分裂症的预后和远期疗效。方法 对33例接受氯氮平治疗的精神分裂症患者进行定期门诊随访3年，并以简明精神病评定量表（BPRS）、副反应量表（TESS）进行疗效和副反应评定。结果 33例精神分裂症患者的再入院率为78．79％（26／33），临床总有效率为84．84％，但临床副作用多而严重。结论 氯氮平治疗精神分裂症具有良好的临床疗效和远期效应，但副作用仍不容忽视。

Three-year Follow-up Study of Clozapine for Schizophrenia

Objective To explore outcome and long-term response patterns of clozapine treatment of patients with schizophrenia.Methods 33 patients were accepted clozapine treatment only and followed 3 years by regular clinic visits. Using the BPRS, TESS to evaluate the efficacy.Results The rate of patients with re- admission was 78.79%(26/33) and the responded rate to clozapine was 84.84%. But side effects rate and serious adverse were more and worse.Conclusions The clozapine treatment of patients with schizophrenia have better efficacy and long-term response, it may be lower the rate of relapse and re-admission, but the side effects are not neglected.