福州地区质粒介导淋球菌耐药性监测

目的：明确福州地区由质粒介导产生青霉素酶淋球菌(PPNG)菌株和由质粒介导产生高度耐四环素的淋球菌(TRNG)菌株的流行状况，以制定有效的淋病防治方案。方法：采用纸片酸度法和ⅧC测定法连续检测1999年～2002年间淋球菌分离株的质粒介导耐药情况。结果：4年来，共检测了698株临床分离的淋球菌菌株，PPNG流行率由1999年2．2％上升为2002年8．72％，TRNG由0．6％上升为20．69％。结论：福州地区PPNG、TRNG检查率呈逐年上升趋势，持续监测淋球菌PPNG菌株、TRNG菌株的流行情况，对淋病的防治有重要意义。

Surveillance of Plasmid-mediated Resistant Strains of Neisseria Gonorrhoeae in Fuzhou

Objective:To study the prevalent trends of plasmid-mediated resistance of Neisseria gonorrhoeae strains in Fuzhou from 1999 to 2002. Methods: The plasmid-mediated resistance to tetracycline (TRNG) were determined by agar dilution method and penicillinase-producing N. gonorrhoeae (PPNG) by acidometric method. Results: A total of 698 isolated gonococcal strains were tested in the past four years. The rates of PPNG increased from 2.2% to 8.72% and TRNG from 0.6% to 20.69%. Conclusion: The prevalence of plasmid-mediated resistant N. Gonorrhoeae increased year by year in Fuzhou. It is important to survey the plasmid-mediated resistant strains of Neisseria gonorrhoeae consecutively in controlling gonorrhea.