| 卡托普利和氯沙坦对缺血性急性肾衰大鼠抗氧化作用研究 |
| |
| 引用本文： | 黄新武,吴章怀,李华,张红,刘剑. 卡托普利和氯沙坦对缺血性急性肾衰大鼠抗氧化作用研究[J]. 泸州医学院学报, 2010, 33(2): 144-146 |
| |
| 作者姓名： | 黄新武 吴章怀 李华 张红 刘剑 |
| |
| 作者单位： | 泸州医学院药学院药理教研室,四川,泸州,646000 |
| |
| 摘 要： | 目的：观察卡托普利和氯沙坦对缺血性急性肾衰大鼠SOD、MDA及NO的影响。方法：采用切除大鼠右肾,同时阻断左侧肾动脉45min,再灌注24h建立大鼠缺血性急性肾衰竭的动物模型,设立假手术组、模型组、卡托普利组、氯沙坦组及联合用药组,各用药组灌胃给药7天后采用比色法测定各组大鼠肾组织和血浆SOD活性、MDA含量及肾组织中NO的含量。结果：卡托普利,氯沙坦均可升高缺血性急性肾衰大鼠肾组织和血浆SOD活性,明显降低肾组织中MDA和NO含量,但两者合用对其影响与单用无统计学意义。结论：卡托普利和氯沙坦可升高肾组织和血浆SOD活性及降低肾组织MDA和NO含量对缺血性急性肾衰大鼠的损伤起保护作用,两者合用较单用无明显差异。
|
| 关 键 词： | 卡托普利 氯沙坦 缺血性急性肾衰 SOD MDA NO |
EFFECT OF KAPTOPRIL AND LOSARTAN ON FREE RADICAL AND NITRIC OXIDE CHANGE AFTER IARF IN RATS |
| |
| Huang Xinwu,et al. EFFECT OF KAPTOPRIL AND LOSARTAN ON FREE RADICAL AND NITRIC OXIDE CHANGE AFTER IARF IN RATS[J]. Journal of Luzhou Medical College, 2010, 33(2): 144-146 |
| |
| Authors: | Huang Xinwu et al |
| |
| Affiliation: | Huang Xinwu,et al Department of Pharmacology,Luzhou Medical College |
| |
| Abstract: | Objective:To observe the effect of kaptopril and losartan on free radical and nitric oxide (NO) change after ischemic acute renal failure (IARF) in rats.Methods:The animal models were established by bilateral clipping of renal arteries for 45min and reperfusion for 24 hours.Rats were assigned into sham,model,kaptopril-treated,losartan-treated and kaptopril-losartan-treated groups,the drug was fed to the experimental rats for 7-days,respectively.Changes of the activity of superoxide dismutase (SOD) and the c... |
| |
| Keywords: | SOD MDA NO |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
