| 难治性抑郁症认知性电位P_(300)的实验研究 |
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| 引用本文： | 王勇,方贻儒,陈兴时,陈俊,吴志国,苑成梅,楼翡璎,梁建华,陈冲,洪武,易正辉,胡莺燕,曹岚,李则挚,黄佳.难治性抑郁症认知性电位P_(300)的实验研究[J].上海精神医学,2008,20(6). |
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| 作者姓名： | 王勇 方贻儒 陈兴时 陈俊 吴志国 苑成梅 楼翡璎 梁建华 陈冲 洪武 易正辉 胡莺燕 曹岚 李则挚 黄佳 |
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| 作者单位： | 上海交通大学医学院,附属精神卫生中心,200030 |
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| 基金项目： | 国家科技攻关计划
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国家高技术研究发展计划(863计划)
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上海市登山行动计划
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| 摘 要： | 目的 研究难治性抑郁症患者的认知性电位P300特点,探讨其认知功能缺陷可能的电生理学机制. 方法 应用美国Nicolet Bravo脑电生理仪,刺激采用纯音"Oddball"诱发模式,对50例难治性抑郁症患者和52名正常人进行了认知性电位P300检测. 结果 ①与正常对照组相比,难治性抑郁症组P300基本波形变异大,稳定性差.②与正常对照组相比,难治性抑郁症组的非靶指标均表现为潜伏期延长和波幅降低(非靶N1潜伏期t=3.970,P<0.01,波幅t=-2.524,P<0.05;非靶P2潜伏期t=3.263,P<0.01,波幅t=-3.937,P<0.01).③与正常对照组相比,难治性抑郁症组的靶指标除了靶P2和靶N2的波幅差异无统计学意义外,均表现为潜伏期显著延长和波幅显著降低(靶N1潜伏期t=4.790,P<0.01,波幅t=-2.151,P<0.05;靶P2潜伏期t=4.692,P<0.01;靶N2潜伏期t=9.601,P<0.01;靶P3潜伏期t=9.935,P<0.01,波幅t=-5.680,P<0.01). 结论 难治性抑郁症患者领悟等认知功能的损害可能更为严重,P300有可能是难治性抑郁症特定的脑电生物学标志.
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| 关 键 词： | 难治性抑郁症 认知性电位 认知功能 生物学标志 |
Experimental study of cognition potential P_(300) in treatment-resistant depression |
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| Wang Yong,Fang Yiru,Chen Xingshi,Chen Jun,Wu Zhiguo,Yuan Chengmei,Lou Feiying,Liang Jianhua,Chen Chong,Hong Wu,Yi Zhenghui,Hu yingyan,Cao Lan,Li Zezhi,Huang Jia.Experimental study of cognition potential P_(300) in treatment-resistant depression[J].Shanghai Archives of Psychiatry,2008,20(6). |
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| Authors: | Wang Yong Fang Yiru Chen Xingshi Chen Jun Wu Zhiguo Yuan Chengmei Lou Feiying Liang Jianhua Chen Chong Hong Wu Yi Zhenghui Hu yingyan Cao Lan Li Zezhi Huang Jia |
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| Institution: | Wang Yong,Fang Yiru,Chen Xingshi,Chen Jun,Wu Zhiguo,Yuan Chengmei,Lou Feiying,Liang Jianhua,Chen Chong,Hong Wu,Yi Zhenghui,Hu yingyan,Cao Lan,Li Zezhi,Huang Jia.Shanghai Mental Health Center,Shanghai Jiaotong University,Shanghai 200030 |
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| Abstract: | Objective: To investigate the characteristics of P300 in patients with treatment-resistant depression.Methods: P300 were recorded in 50 treatment-resistant depression patients and 52 normal controls by the standard oddball paradigm presented with auditory double clicks stimuli,using American Nicolet Bravo instrument.Results:Compared with the control group,the treatment-resistant depression group showed obviously irregular forms of P300 wave,and the latencies of major components of both target P300 and non-t... |
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| Keywords: | P300 |
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