KAI1/CD82和MMP-9在胃癌中的表达及临床意义

目的 检测KAI1／CD82和MMP-9在胃癌中表达，探讨其与预后的关系。方法 应用免疫组化法检测KAI1／CD82，MMP-9基因蛋白在68例胃癌组织中的表达，对35例随访病例进行生存分析。结果 68例胃癌组织KAI1／CD82阳性表达率26．47％，MMP一9阳性表达率86．76％；KAI1／CD82在高分化胃腺癌阳性表达率比低分化者高，MMP-9无差异；无淋巴结转移胃癌的KAI1／CD82阳性表达率比有淋巴结转移者高，MMP-9则低；KAI1／CD82阳性表达率随浸润深度增加而逐渐降低，MMP-9则逐渐升高。KAI1／CD82在Ⅰ／Ⅱ期胃癌阳性表达率比Ⅲ／Ⅳ期者高，MMP-9无差异。KAI1／CD82阳性患者术后生存率比阴性者显著提高，MMP-9则显著降低。结论 KAI1／CD82在胃癌的表达与肿瘤浸润深度、分化程度、临床分期及淋巴结转移及预后有关；MMP-9在胃癌的表达与肿瘤浸润深度、淋巴结转移及预后有关。

The expression and clinical significance of KAI1/CD82 and MMP-9 in gastric adenocarcinoma

Objective To investigate the expression of KAI1/CD82 and MMP-9 in gastric carcinoma,and its significance in the prognosis of gastric carcinoma.Methods Sixty-eight gastric carcinoma tissues were studied for the expression of KAI1/CD82 and MMP-9 by means of immunohistochemical assay. 35 cases were followed-up and the prognosis was analyzed. Results Eighteen of 68 cases gastric carcinoma were positive for KAI1 (26.4%), while 59 of 68 for MMP-9(86.76% ). KAI1/CD82 positive rate in well-differentiated carcinoma was higher than that in the poorly-differentiated,but MMP-9 positive rate was not.KAI1/CD82 positive rate in the cases without lymph node metastasis was higher than that in those with lymph node metastasis.The reverse was MMP-9 positive rate.With tumor invasion promoting, KAI1/CD82 positive rate was higher and MMP-9 positive rate was lower. KAI1/CD82 positive rate was lower with tumor stage increasing and MMP-9 positive rate was not significantly changed.The expression of KAI1/CD82 and MMP-9 was not correlated with the age and sex. The patients with KAI1/CD82 positive had higher survival rate than those with KAI1/CD82 negative, while the patients with MMP-9 positive had lower survival rate than those with MMP-9 negative.Conclusion The expression of KAI1 was related to the invasion,differentiation,staging,lymph node metastasis and prognosis of the tumor, and the expression of MMP-9 was related to invasion,lymph node metastasis and prognosis of the tumor.