葛根的化学成分研究

目的：从豆科葛属植物云南葛藤Pueraria Peduncularis中分离得到10个化合物。方法：通过波谱和化学方法分别进行鉴定。结果：它们的化学结构为：3－O－β-D－吡喃葡萄糖（1→3)-β-D－吡喃葡萄糖醛酸甲酯苷]－3β-15α，23－三羟基齐墩果－12－烯－16－酮（I），大豆素（Ⅱ），染料木素（Ⅲ），大豆苷（Ⅳ），染料木苷（V），3β，15α－二羟基齐墩果－12－烯－16－酮（Ⅵ），羽扇醇（Ⅶ），桦木酸（Ⅷ），α-波甾醇葡萄糖苷（Ⅸ）和α－菠甾醇（X）。结论：化合物I对黑曲霉具有抑制活性。

Chemical Constituents of Pueraria peduncularis

Object To investigate the chemical constituents from the stem of Pueraria peduncularis (Grah. ex Benth. ) Benth. Methods The constituents were isolated on silica gel column chromatography.Their structures were elucidated by chemical and spectroscopic evidence. Results Ten compounds were comfirmed as 3-O- β-D-glucopyranosyl- ( 1 → 3 )-β-D- 6-O-methyl-glucuronopyranosyl ]- 3β3, 1 Sa, 2 3-trihydroxy-olean-12-en-16-one (Ⅰ), daidzein (Ⅱ), genistein ( Ⅲ ), daidzin ( Ⅳ ), genistin ( V ), 3β3, 15α-dihydroxy-olean-12-en-16-one (VⅥ), lupeol (Ⅶ), betulinic acid (Ⅷ), α-spinasterol-glucopyranoside (ⅨX)and α-spinasterol ( X ). Conclusion Compound I exhibited antimicrobial activity against Aspergillus niger.Compounds Ⅱ～ X were first isolated from this plant.