益气滋阴方调节甲亢模型大鼠甲状腺激素的实验研究

目的观察益气滋阴方(甲亢方)对甲亢大鼠模型的治疗作用。方法将50只大鼠随机分为正常组、甲亢模型组、甲亢方中剂量组、甲亢方高剂量组、西药对照组(每组10只),除正常组外,余4组大鼠每日按75μg/100 g灌服优甲乐(左甲状腺素钠)造成大鼠甲亢模型,正常组给予生理盐水,甲亢方组给予相应剂量的甲亢方内服,西药对照组灌服丙基硫氧嘧啶。21 d后放免法测定血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)含量。结果益气滋阴方能降低甲亢大鼠血清T3、T4、FT3、FT4含量,提高血清TSH。结论益气滋阴方能够显著改善甲亢大鼠甲状腺功能。

Experiment study of Yiqi Ziyin decoction On thyroid hormone in rat models with hyperthyroidism

Objective It is to observation the treatment function of Yiqi Ziyin decoction(hyperthyroidism decoction) on rat models with hyperthyroidism.Methods 50 rats were randomly divided into normal group,hyperthyroidism model group,mild dosage of hyperthyroidism decoction group,high dosage of hyperthyroidism decoction group,western medicine control group.Every group had 10 rats.All the groups except normal group were given Levothyroxine Sodium 75 μg/100 g by drench every day to make hyperthyroidism models.Normal group was given normal saline,hyperthyroidism groups were given hyperthyroidism of respective dosage,and model group was given Propylthiouracil.The serum contents of FT3,FT4,T3,T4 and TSH were determined by radio-immunity method after 21days.Results Hyperthyroidism decoction could decrease the contents of serum FT3,FT4,T3,T4,and increase the content of serum TSH.Conclusion Hyperthyroidism decoction can effectively improve the thyroid gland function of rats with hyperthyroidism.