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An Autopsy Case of Primary Biliary Cholangitis with Histological Submassive Hepatic Necrosis Caused by Acute Hepatitis E Virus Infection |
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| Authors: | Mizuki Koyama Tomoo Yamazaki Satoru Joshita Akihiro Ito Kazuyuki Ono Takayuki Watanabe Yuki Yamashita Ayumi Sugiura Mikiko Kobayashi Yoshinori Sato Masaharu Takahashi Hiroaki Okamoto Takeji Umemura |
| Affiliation: | 1.Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan; 2.Department of Pathology, Shinshu University School of Medicine, Japan; 3.Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Japan; 4.Department of Life Innovation, Institute for Biomedical Sciences, Shinshu University, Japan |
| Abstract: | A 59-year-old woman who had been diagnosed with cirrhotic primary biliary cholangitis (PBC) 5 years earlier was admitted for severe jaundice (total bilirubin: 30.1 mg/dL). We suspected that her cirrhotic PBC had deteriorated acutely for some reason. Her general condition deteriorated quickly, and she passed away on day 18 of admission. Hepatitis E virus (HEV)-IgA antibodies were positive, and Genotype 3b HEV involvement was confirmed from a blood sample taken on admission. Histopathological findings revealed cirrhosis and submassive loss and necrosis of hepatocytes. Clinicians should consider the possibility of acute HEV infection as a trigger for acute PBC exacerbation. |
| Keywords: | primary biliary cholangitis hepatitis E virus |