Clinical features of type III hyperlipoproteinemia: analysis of 64 patients |
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Authors: | G Feussner A Wagner B Kohl R Ziegler |
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Institution: | (1) Medizinische Klinik der Universität Heidelberg, Abteilung Innere Medizin I Endokrinologie und Stoffwechsel, Bergheimer Strasse 58, W-6900 Heidelberg, Germany |
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Abstract: | Summary The clinical and biochemical characteristics of type III hyperlipoproteinemia are described in 64 patients (35 males and 29 females). Homozygosity for apolipoprotein E2, the presence of an abnormally cholesterol-rich very low density lipoprotein fraction ( -VLDL) and an elevated ratio of very low density lipoprotein cholesterol to plasma triglycerides (>0.3; normal ratio about 0.2) were the basis for the diagnosis. Mean serum cholesterol and triglyceride concentrations at the first visit in the clinic were 426 ± 221 and 719 ±996 mg/dl, respectively. The mean age at diagnosis of the disorder was 49 years in males and 53 years in females. There was a high prevalence of obesity (72%), xanthomas (42%), and atherosclerosis (39%), especially peripheral vascular disease (31%). Early and correct diagnosis of this familial lipoprotein disorder seems necessary because of the prompt and beneficial response to therapeutic interventions.Abbreviations Apo
apolipoprotein
- BMI
body mass index
- CAD
coronary artery disease
- HDL
high-density lipoproteins
- HLP
hyperlipoproteinemia
- HMG CoA
3-hydroxy-3-methylglutaryl coenzyme A
- LDL
low-density lipoproteins
- Lp(a)
lipoprotein (a)
- PVD
peripheral vascular disease
- TG
triglycerides
- VLDL
very low density lipoproteins |
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Keywords: | Apolipoprotein E Atherosclerosis Familial dysbetalipoproteinemia Genetic polymorphism Type III hyperlipoproteinemia |
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