高原红细胞增多症红细胞膜流动性的改变及相关机理

目的：测定高原红细胞增多症（ＨＡＰＣ）患者红细胞膜流动性，了解过氧化脂质和超氧化物歧化酶对红细胞膜流动性的影响，为临床治疗提供依据。方法：ＨＡＰＣ患者２７例，正常对照２３例。测定红细胞膜流动性，红细胞膜过氧化脂质，血浆和红细胞超氧化物歧化酶活力。结果：ＨＡＰＣ患者红细胞膜荧光偏振度与对照组比较增加（Ｐ〈０．０１）。红细胞膜过氧化脂质与对照组比较增高（Ｐ〈０．０１）。血浆及红细胞超氧化物歧化酶与对照

THE CHANGE OF MEMBRANE FLUIDITY OF ERYTHROCYTE IN PATIENTS WITH HIGH ALTITUDE POLYCYTHEMIA AND THE RELATED MECHANISM

Objective: To explore the effects of lipid peroxide and superoxide dismutase(SOD) on membrane fluidity of erythrocyte in patients with high altitude polycythemia (HAPC) and to provide basis for clinical treatment. Methods: The membrane fluidity of erythrocyte, MDA content in erythrocyte membrane, serum SOD and RBC SOD were measured in 27 HAPC patients and 23 healthy individuals. Results: The membrane fluorescence polarization degree of erythrocyte was significantly increased and the membrane fluidity of erythrocyte remarkably decreased ( P<0.01, P<0.01 ). Linear regression analysis showed that fluorescence polarization degree of the erythrocyte membrane was positively correlated with MDA ( r=0.4133, P<0.05 ), but negatively correlated with serum SOD and RBC SOD ( r=-0.3915, P<0.05 , and T5BX]r=-0.4117,P<0.05 ,respectively) in the patients with HAPC. HZConclusion: The membrane fluidity of erythrocyte decreased in patients with HAPC. The increase of MDA content and decrease of SOD activity are important factors affecting membrane fluidity of erythrocyte.