Treatment of severe refractory pemphigus vulgaris with rituximab |
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| Authors: | Pitarch Gerard Sánchez-Carazo José L Pardo José Torrijos Arantxa Roche Elena Fortea José M |
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| Institution: | Servicio de Dermatología, Hospital General Universitario de Valencia, Spain. gerardpitarch@hotmail.com |
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| Abstract: | Pemphigus vulgaris is a potentially fatal autoimmune bullous disease. High doses of immunosuppressive drugs are used in managing severe cases of pemphigus. Rituximab, an anti-CD20 monoclonal antibody, has proven to be effective in patients with refractory pemphigus vulgaris and pemphigus foliaceus. We review cases of pemphigus vulgaris and pemphigus foliaceus not associated with lymphoma that were treated with rituximab, and we report a new case of severe refractory pemphigus vulgaris successfully treated with rituximab. |
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