High frequency intergenomic recombination of suid herpesvirus 1 (SHV-1, Aujeszky's disease virus) |
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Authors: | L. S. Christensen B. Lomniczi |
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Affiliation: | (1) State Veterinary Institute for Virus Research Lindholm, Denmark;(2) Veterinary Medical Research Institute Hungarian Academy of Sciences, Budapest, Hungary |
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Abstract: | Summary Examples are given of observations made with field isolates of suid herpesvirus 1 (SHV-1) which indicate that intergenomic recombination is a common phenomenon associated with the virus. This was further confirmed by experimental co-infection of a pig with 2 virus strains with different, stable and easily identifiable genomic markers, followed by natural transmission to a group of contact pigs. A variety of recombinants was subsequently isolated, while none of the parental strains were re-isolated from any of the pigs. It is suggested that co-invasion of cells and recombination between viral genomes play a role in the life cycle of the virus. |
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