| AQP1、AQP3和AQP8在子宫颈癌中的表达研究 |
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| 引用本文： | 史永华,陈锐,拉莱·苏祖克. AQP1、AQP3和AQP8在子宫颈癌中的表达研究[J]. 实用肿瘤杂志, 2012, 27(1): 18-21 |
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| 作者姓名： | 史永华 陈锐 拉莱·苏祖克 |
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| 作者单位： | 1. 新疆医科大学基础医学院病理教研室,新疆乌鲁木齐,830011
2. 新疆医科大学第三附属医院妇科,新疆乌鲁木齐,830014 |
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| 基金项目： | 国家自然科学基金地区基金 |
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| 摘 要： | Objective: To probe expression and significance of AQP1, AQP3 and AQP8 in cervical carcinoma. Methods: The expressions of AQP1, AQP3 and AQP8 in SiHa cell line were examined by RT-PCR and immunofluorescence and in 35 cases of cervical carcinoma, 15 cases of CIN3 and 15 cases of control group by immunohistochemistry. Results: (1) AQP1, AQP3 and AQP8 expressed in SiHa cell line; (2)MVD of AQP1 were 43.6±17.8, 56.2±11.6, 70.8±21.1 in control group, CIN3 and cervical carcinoma group, respectively. The difference among three groups was significant(P<0.05). Positive rates of AQP3 were 13.3%, 26.7%, 48.6%, respectively, in control group, CIN3 and cervical carcinoma group. The difference between cervical carcinoma and control group was significant(P<0.05). Positive rates of AQP8 were 46.7%, 86.7%, 54.3%, respectively, in three groups. The difference among three groups was significant(P<0.05). Conclusion: Expression of AQP1, AQP3 and AQP8 in cervical carcinoma might be related with cervical carcinogenesis and development.
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| 关 键 词： | 宫颈肿瘤 膜蛋白质类 肿瘤细胞,培养的 免疫组织化学 |
Research on expression of AQP1, AQP3 and AQP8 in cervical carcinoma |
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| SHI Yong-hua , CHEN Rui , Lalai suzuke. Research on expression of AQP1, AQP3 and AQP8 in cervical carcinoma[J]. Journal of Practical Oncology, 2012, 27(1): 18-21 |
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| Authors: | SHI Yong-hua CHEN Rui Lalai suzuke |
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| Affiliation: | SHI Yong-hua,CHEN Rui,Lalai.suzuke(1.Department of Pathology,Basic Medicine School of Xinjiang Medical University,Urumqi,830011,China; 2.Department of Gynecology,The Third Affiliated Hospital of Xinjiang Medical University,Urumqi,830014,China) |
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| Abstract: | Objective To probe expression and significance of AQP1,AQP3 and AQP8 in cervical carcinoma. Methods The expressions of AQP1,AQP3 and AQP8 in SiHa cell line were examined by RT-PCR and immunofluorescence and in 35 cases of cervical carcinoma,15 cases of CIN3 and 15 cases of control group by immunohistochemistry. Results（1） AQP1,AQP3 and AQP8 expressed in SiHa cell line;（2）MVD of AQP1 were 43.6±17.8,56.2±11.6,70.8±21.1 in control group,CIN3 and cervical carcinoma group,respectively.The difference among three groups was significant（P〈0.05）.Positive rates of AQP3 were 13.3%,26.7%,48.6%,respectively,in control group,CIN3 and cervical carcinoma group.The difference between cervical carcinoma and control group was significant（P〈0.05）.Positive rates of AQP8 were 46.7%,86.7%,54.3%,respectively,in three groups.The difference among three groups was significant（P〈0.05）. Conclusion Expression of AQP1,AQP3 and AQP8 in cervical carcinoma might be related with cervical carcinogenesis and development. |
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| Keywords: | cervix neoplasms membrane proteins tumor cells cultured immunohistochemistry |
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