鼻咽癌四野面颈联合野适形放疗可行性研究及近期疗效分析

目的本研究采用四野面颈联合野放疗治疗鼻咽癌患者,分析急性放射性反应和近期疗效。方法101例初治鼻咽癌患者进行四野面颈联合野适形放疗,其中90例接受FP方案同步化疗及辅助性化疗。结果患者在7周内完成治疗计划,四野面颈联合野适形放疗获得了满意的剂量分布。鼻咽癌病灶完全缓解(completeremission,CR)为95.0%(96/101),部分缓解(partial remission,PR)5.0%(5/101),总有效率达100.0%,淋巴结病灶CR 90.1%(91/101),PR 6.9%(7/101),总有效率为97.0%,1年总生存率、无瘤生存率分别为100.0%、97.0%,不良反应主要为Ⅰ～Ⅱ级放射性黏膜炎、白细胞下降。结论四野面颈联合野适形放疗剂量分布满意,近期疗效满意,急性放射反应可耐受,远期疗效及组织损伤尚有待长期随访观察。

Feasibility and short-term efficacy of four facio-cervical field conformal radiotherapy for nasopharyngeal carcinoma

Objective To investigate the feasibility and short-term efficacy of four facio-cervical field conformal radiotherapy（4F-CRT） for nasopharyngeal carcinoma（NPC）.Methods One hundred and one patients with histology-confirmed nonmetastatic NPC were enrolled in the study and received 4F-CRT from November 2007 to June 2009,among them 90 received concurrent chemotherapy and adjuvant chemotherapy.Results The treatment was completed for all patients within 7 weeks.The complete response（CR） rate was 95.0%（96/101） and the partial response（PR）rate was 5.0%（5/101）with an overall response of 100.0% for the primary tumors;the CR rate was 90.0%（91/100）and PR rate was 7.0%（7/101）with an overall response of 97.0% for metastatic lymph nodes.The major toxicities observed were grades Ⅰ~Ⅱ mucosis and leukocytopenia.Conclusions 4F-CRT can generate desirable dose distribution of tumor volume for nasopharyngeal carcinoma.The short-term efficacy of 4F-CRT is satisfactory and the acute toxicities are tolerable.