18F-FDG PET/CT对宫颈癌预后的相关研究

因为PET/CT在宫颈癌诊断、分期及指导治疗方面的巨大价值,许多学者开始探索PET/CT在宫颈癌预后方面的价值,尤其是最大标准摄取值(maximum standardized uptake value,SUVmax)在宫颈癌预后方面的作用,研究发现随着治疗前宫颈癌原发病灶或转移淋巴结SUVmax值的升高,患者生存率相应下降,复发率相应升高;并且通过比较宫颈癌原发病灶治疗前后18F-FDG(脱氧葡萄糖)异常浓聚缓解程度来判断预后,完全缓解的患者预后较好,缓解不完全或出现新的18F-FDG异常浓聚的患者预后较差.

The prognostic value of 18F-FDG PET/CT in cervical cancer

Because positron emission tomography （PET）/computed tomography （CT） plays an important role in diagnosis ,clinical staging and optimal treatment of cervical cancer, this leads people to think its value of the prognosis for patients with cervical cancer, especially the value of maximum standardized uptake value（ SUV- max） in the prognosis for patients with cervical cancer. Some studies demonstrate that a high pretreatment glucose analog F- 18fluorodeoxyglucose（FDG） uptakes in the primary tumor or lymph node metastasis at diagnosis. As measured by the SUVmax, it is correlated with a lower survival and higher recurrence rate in patients with cervical cancer. The use of PET with FDG to assess post - therapy glucose metabolism in the primary tumor could predict the prognosis for patients with cervical cancer;a complete metabolic response on PET is predictive of a good survival outcome;a partial metabolic response or progressive disease is predictive of a poor survival outcome.