补康灵对非小细胞肺癌化疗患者生存质量的影响

目的探讨补康灵对非小细胞肺癌化疗患者生存质量的影响。方法将90例中晚期非小细胞肺癌患者随机分为化疗组、补康灵加化疗组、康莱特加化疗组各30例。化疗组:采用TP方案化疗,紫杉醇135～175 mg/m2,d1,顺铂25 mg/m2,d1-3,每21天为1周期。补康灵加化疗组:化疗前1周开始服用补康灵,直至化疗结束后1周,50 mL,bid。康莱特加化疗组:在化疗的基础上静注康莱特注射液100 mL,bid,d1-10。化疗2个疗程后评价疗效。应用卡氏(KPS)评分及肺癌患者生存质量测定量表(QLQ-LC43)评估补康灵联合化疗对非小细胞肺癌化疗患者生存质量的影响。结果补康灵加化疗组治疗后卡氏评分增加稳定率为73.3%,与化疗组比较差异有统计学意义(P<0.05),各组治疗前QLQ-LC43计分无统计学差异(P>0.05),化疗组躯体功能、社会功能、整体健康状况、呼吸困难、肺癌子模块等指标下降,疲倦、食欲缺乏等指标提高,与治疗前比较差异有统计学意义(P<0.05),补康灵加化疗组治疗后躯体功能、角色功能、情绪功能、认知功能、社会功能、整体健康状况指标提高,疲倦、食欲缺乏、呼吸困难、疼痛、失眠、肺癌子模块指标减低,与治疗前比较差异都具有统计学意义(P<0.05或P<0.01)。结论补康灵联合化疗可以明显提高非小细胞肺癌患者的生存质量。

Bukangling combined with chemotherapy improves quality of life in patients with middle-advanced stage non-small cell lung cancer

Objective To evaluate the effect of Bukangling combined with chemotherapy on quality of life in patients with middle-advanced stage non-small cell lung cancer.Methods Ninety patients with middle-advanced non-small cell lung cancer were randomly divided into chemotherapy group（Group A）,Bukangling combined with chemotherapy group（Group B） and Kanglaite combined with chemotherapy group（Group C） with 30 patients in each group.The TP regimen was given to all patients,which consisted of paclitaxel 135~175 mg/m2 d1 and cisplatin 25 mg/m2 d1-d3 with every 21d as 1 cycle.Patients in Group B also received Bukangling 50 mL,bid,from 1 week before till 1 week after chemotherapy;Patients in Group C also received Kanglaite injection 100 mL,bid,d1-10.After 2 courses of chemotherapy,the quality of life of patients was assessed with Karnofsky performance score（KPS） and Quality of Life Questionnaire（QLQ-LC43）.Results The KPS in Group B was increased by 73.3%,which was significantly different from that of Group A（P0.05）.There were no differences in QLQ-LC43 scores among three groups before treatment（P0.05）.After treatment the scores of physical function,social function,overall health,difficulty breathing and other indicators of sub-module were decreased and the scores of fatigue,loss of appetite and other indicators increase in Group A compared to those before treatment（P0.05）.In Group B the scores of physical function,role function,emotional function,cognitive function,social function and overall health were increased;the scores of fatigue,loss of appetite,difficulty breathing,pain,insomnia were decreased after treatment compared with those before treatment（P0.05 or P0.01）.Conclusion Bukangling combined with chemotherapy can improve the quality of life in patients with middle-advanced stage non-small cell lung cancer.