肺癌眼脉络膜转移的临床分析

目的探讨肺癌眼脉络膜转移的临床特点、诊断和治疗。方法采用回顾性研究的方法,对收治的21例肺癌眼脉络膜转移的临床资料进行总结、分析。结果 21例中,以肺部为首发症状的7例,以眼部为首发症状的14例;肺部病变位于左肺12例,右肺9例;中心型8例,周围型13例。眼部病变位于单眼20例,双眼1例,共22只眼受累,左眼13例,右眼9例;病变位置在后极14例,近视乳头5例,脉络膜周边3例。病理类型:肺腺癌13例,小细胞肺癌4例,鳞癌3例,大细胞肺癌1例。18例并发眼以外器官的转移。随访19例,中位生存期12.0月,1年生存率44.7%,2年生存率6.5%。结论肺癌眼脉络膜转移应对其重视及完善检查,使其尽早确诊。恰当的治疗可延长患者的生存期、缓解症状及提高生活质量。

Choroidal metastasis from lung cancer

Objective To review the clinical characteristics,diagnosis and the treatment of choroidal metastasis from lung cancer.Methods Twenty-one cases of choroidal metastasis from lung cancer were collected from Jaunary1987 to December 2010 and the clinical data were analyzed retrospectively.Results Among 21 cases,the pulmonary symptom initially appeared in 7,for rest cases the initial symptoms were found in eyes.The primary lesions were located in left lung in 12 cases and right lung in 9 cases.Eight cases were diagnosed as central lung cancer and 13 cases as peripheral lung cancer.Ocular lesions were found in single eye in 20 cases and both eyes in 1 case.Totally 22 eyes had metastatic lesions,13 of which were left eyes and 9 right eyes.The ocular lesions were found in posterior pole in 14 cases,juxtapapillary in 5 cases and choroidal periphery in 3 cases.Pathological examination identified adenocarcinoma in 13 cases,small-cell carcinoma in 4,squamous cell carcinoma in 3 and of large-cell carcinoma in one.Eighteen cases were accompanied with tumor metastasis outside the eyes.For 19 followed up cases the median survival time was 12.0 months;the 1-year and 2-year survival rates were 44.7% and 6.5% respectively.Conclusion The choroidal metastasis from lung cancer is a rare disease and proper treatment can prolong the survival time,release the symptom and improve the life quality of patients.