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| Jagged-1在子宫颈癌组织中的表达 | |
| 引用本文： | 岳兰,李少红,谭继英,曾峰,张维岳.Jagged-1在子宫颈癌组织中的表达[J].实用肿瘤杂志,2012,27(1):42-45. |
| 作者姓名： | 岳兰 李少红 谭继英 曾峰 张维岳 |
| 作者单位： | 1. 兰州大学基础医学院免疫学研究所,甘肃兰州,730000 2. 兰州大学第一附属医院病理科,甘肃兰州,730000 3. 武警甘肃总队医院病理科,甘肃兰州,730050 |
| 摘 要： | 目的检测Jagged-1在子宫颈癌组织中的表达情况,探讨其在子宫颈癌发生、发展中的作用机制。方法采用免疫组织化学EnVision法检测60例子宫颈癌和21例正常子宫颈组织中Jagged-1的表达情况。结果Jagged-1在子宫颈鳞癌、腺癌组织中及正常组织中的阳性率分别为72.5%、80.0%和23.8%,在子宫颈鳞癌、腺癌组织中的表达水平高于正常子宫颈组织,差异有统计学意义(P<0.05)。结论 Jagged-1在子宫颈癌中的表达升高,提示其可能参与了子宫颈癌的发生、发展过程。 |
| 关 键 词： | 宫颈肿瘤 Jagged-1 免疫组织化学 信号传导 |
Expression of Jagged-1 in cervical carcinoma |
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| Institution: | YUE Lan,LI Shao-hong,TAN Ji-ying,et al(Institute of Immunology,School of Basic Medical Science,Lanzhou University,Lanzhou,730000,China) |
| Abstract: | Objective To explore the expression of Jagged-1 protein and to investgate it′s mechanism in the occurrence and development of cervical cancer. Methods EnVision immunohistochemical technique was used to detect the expression of Jagged-1 protein in 60 cases of cervical cancer and 21 cases of normal cervical tissue. Results The expression rates of Jagged-1 in the cervical squamous cell carcinoma,adenocarcinoma and normal cervical tissue were 72.5%,80.0%,23.8%,respectively,which were higher in cervical squamous cell carcinoma and adenocarcinoma than those in normal cervical tissue(P<0.05). Conclusion The increased expression of Jagged-1 protein may participate in the occurrence and development of cervical cancer. |
| Keywords: | cervix neoplasms Jagged-1 immunohistochemistry signal transduction |
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