肿瘤相关巨噬细胞和MMP-2在成釉细胞瘤中的表达及意义

目的：探讨肿瘤相关巨噬细胞（ TAMs）和基质金属蛋白酶?2（ MMP?2）在人成釉细胞瘤（ ABs）中的表达及意义。方法：采用免疫组化通用二步法，分别检测43例ABs和10例正常口腔黏膜中CD68标记的巨噬细胞数目及MMP?2的表达情况。结果：TAMs和MMP?2在ABs中的表达均高于正常黏膜，差异有统计学意义（ P＜0．01）。在ABs中，TAMs主要表达于肿瘤间质，MMP?2主要表达于肿瘤实质，MMP?2表达强度随着TAMs计数增加而增加，二者呈正相关关系（ r＝0．331，P＜0．05）。结论：ABs中TAMs和MMP?2的共同表达可能在其发生发展中发挥重要作用。

Expression and clinical significance of tumor-associated macrophages and matrix metalloproteinase-2 in ameloblastomas

Objective:To investigate the expression and clinical significance of tumor?associated macrophages(TAMs) and matrix metalloproteinase?2( MMP?2) in ameloblastomas( ABs) . Methods:The expression of TAMs( CD68) and MMP?2 was examined in 43 ABs and 10 normal oral mucosa by universal two?step immunohistochemical technique. Results:Expression of TAMs and MMP?2 were significantly higher in ABs compared with normal oral mucosa(P<0.01). TAMs was mainly expressed within the stroma and MMP?2 was mainly expressed within the islands of ABs. There was a positive correlation between MMP?2 score and TAMs count in ABs( r=0.331, P<0.05) . Conclusions:The common expression of TAMs and MMP?2 may play an important role in the development of ABs.