变形链球菌葡聚糖结合蛋白研究进展

葡聚糖结合蛋白是变形链球菌致龋的重要毒力因子。与变形链球菌的粘附、聚集、细胞壁生理功能、酶活性和形成生物膜并维持其结构稳定起重要作用。该文就变形链球菌4种葡聚糖结合蛋白研究现状,葡聚糖结合蛋白与生物膜、防龋疫苗的关系及当前存在的问题作一综述。

Research progress of streptococcus mutans glucan-binding proteins

Glucan?binding proteins (Gbps) are important virulence factors in the cariogenicity of streptococcus mutans (S.mutans). Glucan?binding proteins play an important role in the adhesion and aggregation of S.mutans, and are involved in physiological function of cell wall and enzyme activity;they also have an effect on the biofilm formation and maintain the stability of biofilm architecture. The article reviewed current status of four glucan?binding proteins, their relationships with biofilm and anti?caries vaccine, and existing problems.