| 天疱疮临床诊疗研究进展 |
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| 引用本文： | 杨丽群,范媛. 天疱疮临床诊疗研究进展[J]. 口腔医学, 2016, 0(9): 852-856 |
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| 作者姓名： | 杨丽群 范媛 |
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| 作者单位： | 南京医科大学口腔疾病研究江苏省重点实验室，南京医科大学附属口腔医院黏膜科，江苏南京 210029 |
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| 基金项目： | 国家自然科学基金(81470748)；江苏省高校优势学科建设工程资助项目(2014-37) |
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| 摘 要： | 天疱疮(pemphigus)是一类累及皮肤和黏膜的自身免疫性疱病,基本病理变化为棘细胞层松解。患者血清内存在针对主要抗原为桥粒芯蛋白(desmoglein,Dsg)的自身抗体,该抗体是诊断天疱疮的免疫学指标,同时与病情变化相关。糖皮质激素是治疗天疱疮的首选药物,然而如何制定最佳的治疗方案,依赖于一个能准确评估病情严重程度、稳定合理的评分系统。该文将对近年来天疱疮的诊断、病情评分系统以及治疗的研究进展作一报道。
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| 关 键 词： | 天疱疮 诊断 评分系统 治疗 |
Research progress of the clinical diagnosis and treatment of pemphigus |
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| Abstract: | Pemphigus is an autoimmune bullous disease affecting the skin and mucosa. Its basic pathological change is acantholysis. Desmoglein ( Dsg) antibodies in the serum of patients are the immunological indicator for the diagnosis of pemphigus and correlate with illness changes. Glucocorticoid is the first choice for treatment. However, how to work out the best therapy relies on a stable and reason?able scoring system with an accurate assessment of disease severity. This paper will report the research advances in the diagnosis, sco?ring system and treatment of pemphigus in recent years. |
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| Keywords: | pemphigus diagnosis scoring system treatment |
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