急性脑挫伤患者脑脊液神经元特异性烯醇化酶的变化及意义

目的 :探讨急性脑挫伤患者脑脊液中神经元特异性烯醇化酶 (Neuron -specificenolase,NSE)的变化。方法 :用放射免疫双抗体夹心法对 2 4例广泛脑组织挫伤组 ,30例局部脑挫伤及正常对照组脑脊液NSE含量进行测定。并测定各组冬氨酸转氨酶 (Aspartatetranscarbamoylsse ,AST)水平。结果 :弥漫性脑挫伤患者脑脊液NSE浓度为 (2 5 .43± 5 .6 1)ng/ml,局灶性脑挫伤组为 (14.6 1± 7.5 2 )ng/ml,对照组为 (7.81± 3.2 1)ng/ml,脑挫伤组明显高于对照组 (P <0 .0 5 ) ,且弥漫性脑挫伤组与局灶性脑挫伤组差异显著 (P <0 .0 5 )。脑挫伤组中AST明显高于对照组 ,但AST在广泛脑挫伤组与局部脑挫伤组中无明显差异。结论 :急性脑挫伤患者的NSE、AST水平升高 ,且NSE与脑挫伤体积相关 ,NSE可反映挫伤及其严重程度

NEURON-SPECIFIC ENOLASE LEVELS IN THE CEREBROSPINAL FLUID OF ACUTE BRAIN CONTUSION PATIENTS

Objective To observe the variations of neuron-s pecific enolase (NSE) in the CSF of acute brain contusion patients. Methods NSE, AST were measured in widespread brain contusion group (group 1), part brain contusion group (group 2) and control group (group 3). Results NSE in CSF of group 1 was 25.43±5.61ng /ml, group 2 was 14.61±7.52ng/ml and group 3 was 7.81±3.21ng/ml. The contusion groups were significantly higher than control group (p<0.05). Significant diffe rence was observed between group 1 and group 2. Conclusions NSE levels rise in CSF of acute brain contusion patients, and the levels direct relative with the v olume of contusion. NSE may be a reliance index in judging the degree of brain c ontusion and prognosis.