Cryopyrin-associated periodic syndrome: a case report and review of the Japanese literature |
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Authors: | Aoyama Kumi Amano Hiroo Takaoka Yuki Nishikomori Ryuta Ishikawa Osamu |
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Affiliation: | Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. kumako@ac.auone-net.jp |
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Abstract: | Cryopyrin-associated periodic syndrome is an autoinflammatory syndrome caused by mutations of the CIAS1 gene (currently named NLRP3), and is characterized by periodic attacks of an urticaria-like rash, fever, head-ache, conjunctivitis and arthralgia. We report here a case of a 1-year-old boy with cryopyrin-associated periodic syndrome, which manifested as a recurrent skin rash in the postnatal period. Genetic analysis revealed a missense mutation of the CIAS1 gene in the mother and infant. |
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