角蛋白在肿瘤病理鉴别诊断中的应用

应用免疫组织化学PAP法.对60例不同起源的肿瘤进行角蛋白酶标观察。结果表明:鳞状细胞癌,基底细胞癌,移行上皮细胞癌均呈阳性反应;腺癌细胞角蛋白着色较鳞癌弱,绝大多数呈阳性反应(20/21);肺未分化小细胞癌部分呈阳性反应(4/7);而间叶起源的恶性肿瘤9例.除1例双向分化的滑膜肉瘤为阳性外.其余均为阴性。角蛋白免疫组化染色在恶性肿瘤的鉴别诊断.确定其组织来源等方面都有实用意义。

THE USE OF KERATIN IN THE PATHOLOGICAL DFFERENTIAL DIAGNOSIS OF MALIGNANT TUMORS

Keratin was applieded to tissues sections of 60 human malignant neoplasm using the immunoperoxidase techniques (PAP method), ft was found that carcinomas derved from squmous epithaliun. transitional epithaliun and basal cell were showed strongly positive reactions. Most of the adenocarcinomas (20/21) and some of the undifferentied small cell carcinomas of lung (1/7) were also positive reactions. Keratin-negative reactions occurred in various types of mesenchymal malignant neoplasm except biphasic synovial sarcoma. We consider that Iteration as tumor marker is a very useful determinant of histogenesis and differential diagnosis for pathologist.