尿肺炎链球菌抗原检测儿童肺炎链球菌性肺炎的研究

目的:探讨尿肺炎链球菌抗原用于辅助诊断儿童肺炎球菌性肺炎的临床意义。方法:选择2011年5月-2012年5月我院儿科≤5岁有呼吸道感染的儿童病例,对患儿同时采集尿标本、血标本,尿标本用胶体金法测定尿肺炎链球菌抗原,血标本进行标准培养、鉴定试验。结果:276例患儿中,尿肺炎链球菌抗原阳性率16.3%,血培养阳性率9.4%,肺炎链球菌抗原阳性组尿肺炎链球菌抗原阳性率(88.5%)显著高于阴性组(8.8%)(P<0.01)。胶体金法测定尿肺炎链球菌抗原的敏感性、特异性和准确度分别为88.5%、91.2%和90.9%。结论:尿肺炎链球菌抗原可用于儿童肺炎链球菌性肺炎的辅助诊断依据。

Detection of Streptococcus Pneumoniae Antigen in Urine and Study on Pneumococcal Pneumonia in Children

Objective:To explore the usefulness of pneumococcal antigen test for diagnosis of pneumococcal pneumonia in children.Methods:Choose May 2011 to May 2012 our hospital pediatric cases of respiratory tract infections in children under 5 years old,for each training while collecting blood and urine samples of children with,with colloidal gold method for the determination of urinary streptococcus pneumoniae antigens,standard culture method on blood test.Results:In 276 cases children,streptococcus pneumoniae antigen positive rate 16.3%,blood culture positive rate of 9.4%,streptococcus pneumoniae antigen positive group(88.5%) streptococcus pneumoniae-positive urine rate significantly higher than the negative group(8.8%)(P<0.01).Colloidal gold determination by mother of streptococcus pneumoniae antigen sensitivity,specificity and accuracy,respectively were 88.5%,91.2% and 90.0%.Conclusion:Streptococcus pneumoniae antigen in urine can be used for assisted diagnosis of pneumococcal pneumonia in children.