喜炎平注射液治疗小儿秋季腹泻疗效的荟萃分析

目的:系统评价喜炎平注射液治疗小儿秋季腹泻的疗效和安全性.方法:检索中国知网(CNKI)、维普资讯网(VIP)和万方数据库中1989-2010年的相关文献,收集有关喜炎平注射液治疗小儿秋季腹泻的随机对照临床试验,由两名评价员独立评价纳入文献的质量,并进行异质性检验、荟萃分析和漏斗图分析.结果:共有22项研究符合纳入标准,其方法学质量均为C级.与对照组相比,喜炎平注射液治疗小儿秋季腹泻更为有效[比值比(OR) =4.95,95％置信区间(CI)=(3.84,6.39),P＜0.00001];退热时间更短[标准化均数差(SMD) =-0.72,95％CI=(-0.86,-0.57),P＜0.00001];止泻时间更短[加权均数差(WMD) =-1.41,95％CI=(-1.81,-1.00),P＜0.00001].结论:喜炎平注射液具有治疗小儿秋季腹泻的作用,但不能排除文献质量低和发表性偏倚的缺陷.

Meta analysis of the efficacy of Xiyanping injection in the treatment of autumnal diarrhea in children

Objective: To evaluate the efficacy and safety of Xiyanping injection in the treatment of autumnal diarrhea in children with meta analysis.Methods: Related literature about randomized control trials in the treatment of autumnal diarrhea in children with Xiyanping injection published during 1989-2010 were collected from Chinese National Knowledge Infrastructure(CNKI),VIP database and Wanfang database,and evaluations were made by two reviewers independently.The data were statistically analyzed by difference examination,meta and funnel plot analysis.Results: Twenty-two researches met the accepting criteria and their methodological quality was all grade C.Compared with the control group,Xiyanping injection is more effective to autumnal diarrhea in children [odds ratio(OR) 4.95,95% confidence interval(CI,3.84,6.39),P<0.000 01],shorter onset time of antifebrile effect[standard mean difference(SMD)-0.72,95% CI(-0.86,-0.57),P<0.000 01] and faster antidiarrheal effect[weighted mean difference(WMD)-1.41,95%CI(-1.81,-1.00),P<0.000 01].Conclusion: Xiyanping injection is effective in the treatment of autumnal diarrhea in children.However,the defect of poor literature quality and publication bias can’t be excluded.