调营饮对小鼠S180肝癌腹水模型腹膜淋巴孔直径、面积、周长及密度的影响

目的探讨调营饮对小鼠S180肝癌腹水模型腹膜淋巴孔的影响。方法取S180细胞接种于小鼠腹腔造成肝癌腹水模型,随机分为空白对照组（NS）、模型组（M）、调营饮低剂量组（TA）、调营饮高剂量组（TB）、模型＋NO供组（NO）、调营饮高剂量组＋NOS抑制剂组（NOS）,造模后第5d用调营饮连续灌胃,观察对小鼠腹膜淋巴孔的影响。结果 TA组和TB组腹膜淋巴孔的平均周长、平均面积和平均密度均明显大于NS组和M组（P〈0.01）,NO组腹膜淋巴孔平均周长、平均面积和平均密度明显大于相对应的M组（P〈0.01）,NOS组的腹膜淋巴孔平均周长、平均面积和平均密度明显少于相对应的TB组（P〈0.01）,TA与TB组比较差异无统计学意义（P〉0.05）。结论调营饮对小鼠S180肝癌腹水模型有明显促进腹膜淋巴孔开放面积增大、周长和分布密度增加的作用,可能是其消腹水作用机制之一。

Effect of TIAOYINYIN Mixture of Peritoneal Lymphatic Stomata

Objective To study effect of TIAOYINYIN mixture on concentration of the peritoneal lymphatic stomata in S180 ascites liver cancer mice,such as diameter、number of opening and density of distribution.Methods Sixty special pathogen free(SPF) Kunming mice were randomized into 6 groups: blank contral group(NS),model contral group(M),low TIAOYINYIN mixture model group(TA),high TIAOYINYIN mixture model group(TB),NO supplie group(NO) and NO suppressor group(NOS).Make the mold 5nd days to start for the medicine,after 9nd measure the mice.Results Compared to NS group and model group,TIAOYINYIN mixture could significantly enhance diameter enlarged,number of opening and density of distribution(P <0.05 or P <0.01).Conclusion These experiment study showed SHUILV Mixture regulating peritoneal lymphatic stomata,improving the drainage from peritoneal cavity in the malignant ascites.