Acute kidney injury due to deferoxamine in a renal transplant patient. |
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| Authors: | Christian Clajus Jan U Becker Dirk O Stichtenoth Jessica Wortmann Anke Schwarz Jan T Kielstein |
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| Institution: | Department of Nephrology, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. |
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| Abstract: | |
Introduction
| Deferoxamine is an iron-chelating agent, used in the treatmentof acute iron intoxication and chronic iron overload secondaryto multiple blood transfusions. Moreover it is currently recommendedby the K/DOQI clinical practice guidelines for bone metabolismand disease in chronic kidney disease (CKD) for treatment insymptomatic aluminium toxicity 1]. Deferoxamine is known tohave many adverse effects, some of them potentially fatal, especiallyinfections with siderophilic organisms like mucormycosis 2].We report a case of acute tubular injury in a renal transplantrecipient secondary to treatment with deferoxamine due to ironoverload, in the context of autoimmune haemolytic anaemia.
Case report
| A 58-year-old Caucasian male, with 21-year status post-cadaverkidney transplantation due to Goodpasture's syndrome, presentedwith a sudden rise in serum creatinine from 120 µmol/Lto 250 µmol/L (Figure 1
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| Keywords: | chronic kidney disease deferoxamine renal biopsy toxicity |
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