Modification of human serum albumin binding of methotrexate by folinic acid and certain drugs used in cancer chemotherapy |
| |
Authors: | P Coassolo M Valentin M Bourdeaux C Briand |
| |
Institution: | (1) Laboratoire de Physique Pharmaceutique, Faculté de Pharmacie, Marseille, France |
| |
Abstract: | Summary The binding of methotrexate (MTX) and citrovorum factor (CF) to human serum albumin (HSA) was investigated. The affinity constant for MTX was 820 M–1, with 2 binding sites, and for CF 2340 M–1, with 1.5 binding sites. MTX and CF, which are used together in high dose therapy, compete for HSA binding. Competition for HSA binding between MTX and adriamycin, bleomycin and cyclophosphamide, drugs often used in association with MTX in cancer chemotherapy, was also demonstrated. The clinical importance of such competition depends on the drug/protein concentration ratio which is extremely variable. |
| |
Keywords: | methotrexate citrovorum factor cyclophosphamide adriamycin bleomycin protein binding competitive binding |
本文献已被 SpringerLink 等数据库收录! |
|