| 原发性肾病综合征患者体内氧化及抗氧化系统改变的探讨 |
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| 引用本文： | 牛爱军,涂晓文,张爱平,丁尧海.原发性肾病综合征患者体内氧化及抗氧化系统改变的探讨[J].中国现代医学杂志,2002,12(24):47-49. |
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| 作者姓名： | 牛爱军 涂晓文 张爱平 丁尧海 |
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| 作者单位： | 1. 济南军区总医院实验诊断科,济南,250031
2. 济南军区总医院肾内科,济南,250031 |
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| 摘 要： | 目的 :探讨原发性肾病综合征 (PNS)患者体内氧化损伤状态和抗氧化系统的改变。方法 :测定了 38例肾病综合征患者的血清丙二醛 (MDA)、谷胱甘肽过氧化物酶 (GSH -PX)及血清和红细胞超氧化物歧化酶(SOD)的含量 ,并与正常对照组进行了比较。结果 :38例PNS患者血清丙二醛水平明显高于正常对照组 ,有显著性差异 (P <0 .0 1) ;GSH -PX、血清SOD ,红细胞SOD及SOD/MDA均明显低于正常对照组 ,有显著性差异 (P <0 .0 1)。结论 :脂质过氧化物参与了肾病综合征的致病 ,以及肾病综合征患者抗氧化能力下降导致了肾病综合征患者的发病。
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| 关 键 词： | 肾病综合征(NS) 丙二醛(MDA) 谷胱甘肽过氧化物酶(GSH-PX) 超氧化物歧化酶(SOD) |
| 修稿时间： | 2002年5月3日 |
EFFECT OF OXIDATION SYSTEM AND ANTIOXIDATION SYSTEM ON NEPHROTIC SYNDROME PATIENT |
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| Niu Aijun,Tu Xiaowen,Zhang Aiping,et al..EFFECT OF OXIDATION SYSTEM AND ANTIOXIDATION SYSTEM ON NEPHROTIC SYNDROME PATIENT[J].China Journal of Modern Medicine,2002,12(24):47-49. |
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| Authors: | Niu Aijun Tu Xiaowen Zhang Aiping |
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| Institution: | Niu Aijun,Tu Xiaowen,Zhang Aiping,et al. General Hospital of Jinan Military Region,Jinan 250031 |
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| Abstract: | Objective: To study the change of oxidation system and Antioxidation system on Nephrotie syndrome patient. Method:Serum MDA , GSH-PX, SOD and SOD in red cell of 38 Nephrotic syndrome patients and 16 normal people were detected. Results:The serum MDA level of 38 Nephrotic syndrome patients was significantly higher than that of 16 normal people( P <0.01);the serum GSH-PX,SOD level, SOD in red call and SOD/MDA value were significantly lower than that of 16 normal people( P <0.01).Conclusion: Serum MDA participates in nosogenesis of Nephrotic syndrome,and the decrease of Antioxidation system capability results in Nephrotic syndrome. |
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| Keywords: | Nephrotic Syndrome(NS) MDA GSH-PX SOD |
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