血液透析患者体内肝素/血小板因子4抗体的检测及其临床意义

目的] 本研究的目的是检测89名维持血液透析的患者体内IgG型抗肝素-血小板因子4（H-PF4）抗体发生率，并探讨该抗体的作用。 方法] 取血液透析患者透析前的血清。应用酶联免疫吸附法检测IgG型抗H-PF4抗体。 结果] 在我们的研究中，有8名患者IgG型抗H-PF4抗体阳性(8/89，8.9%)，其中有3人发生了血栓性并发症，抗体阳性组中动静脉血栓性并发症的发生率明显高于抗体阴性组（3/8 vs 8/81， p<0.05）。 结论] IgG型抗H-PF4抗体可能是血液透析患者发生血栓性并发症的危险因素。

Clinical significance of detection of Heparin/Platelet Factor 4 antibody in patients undergoing hemodialysis

Objective]The aim of this study was to determine the prevalence of IgG-H-PF4 antibody in 89 hemodialysis patients and evaluate their effects. Methods] Pre-dialysis blood samples were collected from hemodialysis patients. ELISA was used to detect serum IgG-H-PF4 antibody . Results]In our study, 8 patients were positive for IgG-H-PF4 antibody (8/89,8.9%), of whom three patients experienced thrombosis complications .Thrombosis complications was significantly higher in the IgG-H-PF4 antibody positive group than antibody negative group(3/8 vs 8/81， p<0.05）. Conclusions] IgG-H-PF4 antibody might be a risk factor for thrombosis complications in patients on maintenance hemodialysis.