| 复方青黛颗粒治疗溃疡性结肠炎的机制 |
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| 引用本文： | 邹莉波,刘艳,先宇飞,吴琦,杨新爱,杜立阳. 复方青黛颗粒治疗溃疡性结肠炎的机制[J]. 沈阳药科大学学报, 2006, 23(2): 119-122,128 |
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| 作者姓名： | 邹莉波 刘艳 先宇飞 吴琦 杨新爱 杜立阳 |
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| 作者单位： | 1. 沈阳药科大学,药学院,辽宁,沈阳,110016
2. 中国医科大学,第一临床医院,辽宁,沈阳,110001 |
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| 基金项目： | 辽宁省自然科学基金;辽宁省沈阳市社会发展基金 |
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| 摘 要： | 目的探讨复方青黛颗粒抗实验性溃疡性结肠炎(UC)的作用机制。方法用三硝基苯磺酸(TNBS)法制备大鼠溃疡性结肠炎模型,采用酶联免疫吸附(ELISA)方法测定血清中肿瘤坏死因子(TNF-α)、白细胞介素(IL 1βI、L 4)含量;用流式细胞仪测定结肠组织中CD54阳性细胞率。结果复方青黛颗粒300、600、1 200 mg.kg-1连续灌胃3周,剂量依赖性地降低大鼠血清TNFα及IL 1β水平,升高血清IL 4水平;剂量依赖性地降低动物结肠组织CD54阳性细胞百分率。结论复方青黛颗粒抗实验性溃疡性结肠炎的作用机制可能与下调CD54的过度表达和调节IL 1βI、L 4及TNFCYα水平有关。
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| 关 键 词： | 复方青黛颗粒 溃疡性结肠炎 肿瘤坏死因子 白细胞介素1β、白细胞介素4 CD54 |
| 文章编号： | 1006-2858（2006）02-0119-04 |
| 收稿时间： | 2005-03-17 |
| 修稿时间： | 2005-03-17 |
Mechanisms of Qingdaikeli''''s anti-ulcerative colitis effects |
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| ZOU Li-bo,LIU Yan,XIAN Yu-fei,WU Qi,YANG Xi-nai,DU Li-yang. Mechanisms of Qingdaikeli''''s anti-ulcerative colitis effects[J]. Journal of Shenyang Pharmaceutical University, 2006, 23(2): 119-122,128 |
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| Authors: | ZOU Li-bo LIU Yan XIAN Yu-fei WU Qi YANG Xi-nai DU Li-yang |
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| Abstract: | Objective To investigate the mechanisms of Qingdaikeli(QDK,traditional Chinese medicines).Methods The rat UC model established in our study was induced by TNBS.Serum TNF-α,IL-1β and IL-4 levels were determined by enzymelinked immunosorbent assay.Content of adhesion molecule CD_(54) was determined with flow cytometer.Results Compared with the model group,the serum level of TNFα of QDK-treated rats was significantly decrease on the seventh day.And the administration of QDK markedly decreased the levels of serum IL-1β while the level of serum IL-4 increased compared with model group.The levels of colonic CD_(54) on the twentieth day was markedly decreased after the administration of QDK.(Conclusions) QDK has obvious protective effects against UC in experimental animals. |
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| Keywords: | CD54 |
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