腺苷对病态窦房结综合征与阵发性室上性心动过速影响的研究

目的探讨腺苷对病态窦房结综合征(SSS)和阵发性室上性心动过速的影响。方法17例SSS(1组),19例阵发性室上性心动过速(2组)和46例健康受试者(3组)。用大剂量腺苷及食管调搏术测定窦房结恢复时间(SNRT)、矫正后的窦房结恢复时间(CSNRT)及ADO:CSNRT(腺苷激发后的CSNRT)。结果SNRT长于2200ms和CSNRT长于550ms判定窦房结功能异常。食管调搏法CSNRT1组(3173.80±3377.07)ms,2组(342.59±264.54)ms,3组(282.45±83.24)ms;SNRT1组(4372.80±3159.58)ms,2组(1039.41±322.45)ms,3组(1016.45±85.22)ms;ADO1组(1921.25±1713.65)ms,2组未影响,3组未影响,组间差异有统计学意义(P<0.001)。结论腺苷对SSS的诊断有意义,而对阵发性室上性心动过速无影响。

Clinical study in the diagnosis of sick sinus syndrome and paroxysmal supraventricalar tachycardia

Objective To investigate the sensitivity and specificity of intravenous injection of adenosine in the diagnosis of sick sinus syndrome. Methods We compared the CSNRT and ADO:SCNRT after administration of an intravenous bolus of adenosine in 17 SSS(groups 1) and 19 paroxysmal supraventricalar tachycardia(group 2). Results With 550ms as an abnormal result for the ADO:CSNRT as an indicator of sinus node dysfunction. There was significant difference in the CSNRT and ADO:CSNRT between group 1 and group 2(P<0.001).Conclusion ADO:CSNRT is a sensitive and specific test for SSS that equals invasive testing.