小剂量持续胃肠透析治疗尿毒症临床观察

为评价小剂量持续胃肠透析治疗尿毒症的效果 ,观察了 30例口服胃肠透析液的尿毒症患者治疗效果 ,并与 2 8例口服包醛氧化淀粉的尿毒症患者进行了比较。结果显示 ,小剂量持续胃肠透析治疗后 ,治疗组患者的临床症状改善 ,生活质量提高 ,营养状况良好 ,血肌酐、尿素氮、血磷、血尿酸水平明显下降 ,内生肌酐清除率水平明显升高 ,疗效显著高于对照组 (P <0 .0 1 )。 2组病人的血压、体质量、血浆总蛋白、血浆白蛋白、2 4h尿蛋白及尿量治疗前后均无明显改变。提示 :小剂量持续胃肠透析治疗尿毒症疗效确切 ,可以明显地延缓慢性肾衰竭的进展

Effects of Continuous Gastrointestinal Dialysis with Low Dosage Dialysate in Uremic Patients

To investigate the effect of continuous low dosage gastrointestinal dialysis in uremic patients ,fifty-eight patients with uremia were divided into two groups at random, the treatment group in which thirty patients were given non-absorbed mannitol solution and the control group in which twenty eight patients were given Coated Aldehyde Oxystarch. After treatment, there were significant improvement of uremic symptoms, living quality and nutritional satatus,significant reductions of serum creatinine, blood urea nitrogen,serum phosphorus and uric acid, and significant increment of creatinine clearance in the treatment group. The results of the treatment group was obviously better than that of the control group (P<0.01). Either in treatment group or control group, no significant changes in blood pressure、 body weight、total plasma protein、serum albumin、proteinuria and urine amout were observed. The results showed that the effect of continuous low dosage gastrointestinal dialysis in uremic patients was obvious. It might play an important role in delaying the progression of chronic renal failure.