80例恶性淋巴瘤患者合并乙型肝炎病毒感染的临床分析

目的探讨恶性淋巴瘤患者中乙型肝炎病毒（HBV）的感染率及其与化疗后肝功损害发生和严重程度关系。方法对80例初诊恶性淋巴瘤患者不同性别、年龄、分期、分型中HBV感染进行评价,比较HBV感染的患者与非感染患者在治疗过程中及治疗后肝功损害情况。结果 80例恶性淋巴瘤伴HBV感染者（HbsAg阳性）15例（占18.75%）,男性感染率较女性高,30~60岁组感染率最高,伴HBV感染患者几乎均为非霍奇金淋巴瘤（NHL）患者,分期间感染率差别不大,B细胞与T细胞来源患者间HBV感染无明显差异;伴有HBV感染的恶性淋巴瘤患者化疗过程中肝功损害常见,且程度较严重。结论 NHL伴HBV感染率高,化疗后肝功损害发生率高,提早给予抗HBV病毒治疗可控制HBV复制,同时减轻化疗后肝功损害,为淋巴瘤患者正规治疗提供保障。

Clinical analysis of 80 malignant lymphoma patients with HBV infection

Objective To study the hepatitis B virus（HBV） infection status of the first diagnosed malignant lymphoma patients,and the liver damage status of those patients.Methods We investigated the HBV infection status of 80 malignant lymphoma patients.Results 15 cases（18.75%） had evidence of HBV infection,who were non Hodgkin lymphoma（NHL） patients.There were no difference in different staged and type.During chemotherapy,the frequency of liver dysfunction was higher in cases with HBV infection than that in cases without HBV infection.Conclusion The prevalence of HBV infection was significantly higher in NHL than general population,and the liver dysfunction was frequently occurred in cases of those patients during chemotherapy.