阿立哌唑与利培酮治疗精神分裂症对照研究

目的探讨阿立哌唑治疗精神分裂症的疗效及安全性。方法将60例精神分裂症患者随机分为两组各30例，研究组口服阿立哌唑治疗，对照组口服利培酮治疗，观察8w。于治疗前及治疗第2w、4w、6w、8w末采用阳性与阴性症状量表及副反应量表评定临床疗效和不良反应。治疗前后检查催乳素水平。结果治疗8w末，研究组显效率76．7％，有效率90．0％；对照组分别为73．3％和93．3％，两组比较无显著性差异（P〉0．05）；治疗第2w末起两组阳性与阴性症状量表总分及各因子分均较治疗前有显著下降（P均〈0．01），并随治疗时间的延续呈持续性下降，但两组间同期比较差异无显著性（P〉0．05）。两组治疗前催乳素水平比较无显著性差异，治疗后研究组显著低于对照组（P〈0.01）。两组不良反应均轻微，但研究组静坐不能、体重增加及泌乳、月经紊乱发生率均显著低于对照组（P均〈0．05），而口干发生率显著高于对照组（P〈0．05）。结论阿立哌唑治疗精神分裂症疗效显著，且不影响催乳素水平，安全性高、依从性好。

A control study of aripiprazole vs. risperidone in the treatment of schizophrenia

Objective To explore the efficacy and safety of aripiprazole in the treatment of schizophrenia. Methods Sixty schizophrenia patients were randomly divided into two groups of 30 ones each, research group took orally aripiprazole and control group did risperidone for 8 weeks. Clinical efficacies were assessed with the Positive and Negative Syndrome Scale（PANSS） and adverse reactions with the Treatment Emergent Symptom Scale（TESS） before treatment and at the ends of the 2nd, 4th,6th and 8th week treatment. Prolactin levels were examined before and after treatment. Results At the end of the 8th week, significant efficiency and effective rate was 76.7% and 90.0% in research and 73.3% and 93.3% in the control group,respectively, which showed no significant differences（P〉0.05） ; since the end of the 2nd week,total and all factor score of the PANSS of both groups lowered more significantly compared with pretreatment（all P〈0.01） and did continously along with the time of therapy lasting,but there were no significant differences in synchronization group comparisons（P〉0.05）. Prolactin level in the research had no difference from control group before treatment, but was significantly lower than in the latter after treatment（P〈0.01）. Adverse reactions of both groups were mild, the incidence of akathisia,weight gain, lactation/menstrual disorder was significantly lower（all P〈0.05） and that of dry mouth higher（P〈0.05） in the research than in the control group. Conclusion Aripiprazole has an evident effect on schizophrenia,doesn＇t influence prolactin level,and has higher safety and better compliance.