幽门螺杆菌定植相关致病因子研究进展

幽门螺杆菌(Helicobacter pylori,Hp)感染在世界范围内广泛存在,其感染最基本的条件之一是在胃黏膜的粘附定植。Hp定植因素包括尿素酶活性、鞭毛的动力、特定的形状及粘附素。Hp的适应能力极强,可在同一宿主存活数十年,可能是通过多种受体特异性的粘附素直接与宿主细胞、粘蛋白及细胞外基质结合。Hp粘附于胃黏膜,引起胃上皮细胞IL-8释放,并诱导机体的细胞和体液免疫反应增强,参与疾病的发生发展。本文就Hp定植相关因子的研究进展做一综述。

Pathogenic factors related to Helicobacter pylori colonization

Helicobacter pylori infection is common worldwide.Colonization is a prerequisite for pathogenicity of H.pylori.H.pylori needs to have at least four basic characteristics to be able to colonize gastric mucosa: urease activity,motility of flagella,an integrated helical shape,and specific binding of adhesins and their receptors.The adherence of H.pylori to the host cell,mucin,and extracellular matrices through extensive receptor-specific adhesion is widely assumed to play a substantial role in initial coloniza...