冠心宁片联合西药治疗冠心病稳定型心绞痛临床研究

目的:观察冠心宁片联合西药治疗冠心病稳定型心绞痛的效果及对血脂水平和炎症反应的影响。方法:选取冠心病稳定型心绞痛患者150例,采用随机数表法分为观察组和对照组各75例。对照组给予西医常规治疗,观察组在对照组的基础上联合冠心宁片治疗,2组均以4周为1个疗程,连续治疗3个疗程。比较2组患者血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、单核细胞趋化因子-1(MCP-1)、心绞痛症状评分、中医证候评分及临床疗效。结果:经过治疗,观察组血清TG、TC、LDL-C、hs-CRP、TNF-α、MCP-1水平低于对照组,HDL-C水平高于对照组,差异均有统计学意义(P<0.05)。心绞痛评分及中医证候评分低于对照组,差异有统计学意义(P<0.05)。观察组总有效率为88.00%,高于对照组的73.33%,差异有统计学意义(P<0.05)。结论:使用冠心宁片联合西药治疗冠心病稳定型心绞痛患者,能够显著调节患者血脂水平,抑制炎症反应,改善临床症状,值得推广。

Clinical Study on Guanxinning Tablets Combined with Western Medicine for Stable Angina Pectoris of Coronary Heart Disease

Objective: To observe the clinical effect of Guanxinning tablets combined with western medicine for stable angina pectoris of coronary heart disease,and its effect on blood lipid level and inflammatory reactions. Methods:Selected150 cases of patients with stable angina pectoris of coronary heart disease,and divided them into the observation group and the control group randomly,75 cases in each group. The control group received routine western medicine treatment,while the observation group additionally received Guanxinning tablets. The treatment of both groups lasted for 3 courses continuously, 4 weeks as one course. Compared the levels of total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α) and monocyte chemoattractant protein-1(MCP-1) in serum, symptom scores of angina pectoris,Chinese medicine syndrome scores and clinical effect in both groups. Results:After treatment,the levels of TG,TC, LDL-C, hs-CRP, TNF-αand MCP-1 in serum of patients in the observation group were lower than those in the control group,and the level of HDL-C was higher than that in the control group,differences being significant(P<0.05). The scores of angina pectoris and Chinese medicine syndrome scores in the observation group were respectively lower than those in the control group, difference being significant(P<0.05). The total effective rate was 88.00% in the observation group,being higher than 73.33% in the control group, difference being significant(P<0.05). Conclusion: The application of Guanxinning tablets combined with western medicine for stable angina pectoris of coronary heart disease can significantly regulate the blood lipid level of patients,inhabit inflammatory reactions and improve clinical symptoms,which is worthy of clinical promotion.