滋水清肝饮联合西药治疗肾虚肝郁型卵巢早衰临床研究

目的:观察滋水清肝饮联合西药治疗肾虚肝郁型卵巢早衰(POF)的临床疗效及对患者血清抗苗勒氏管激素(AMH)、基础抑制素B (INHB)及窦卵泡计数(AFC)的影响。方法:选取86例肾虚肝郁型POF患者,按随机数字表法分为对照组和观察组,每组43例。对照组给予戊酸雌二醇片及黄体酮胶囊治疗,观察组在对照组基础上联合滋水清肝饮治疗,2组疗程均为1个月。比较2组中医证候积分,临床疗效和AMH、INHB水平,AFC值。结果:与治疗前比较,治疗后2组月经周期、月经量、月经色及中医证候积分均明显降低,观察组月经周期、月经量、月经色及中医证候积分均较对照组降低更明显,差异均有统计学意义(P<0.05)。观察组总有效率95.35%,高于对照组的76.74%,差异有统计学意义(P<0.05)。治疗后,2组AMH、INHB水平及AFC均较治疗前升高(P<0.05),观察组AMH、INHB水平均较对照组升高更明显(P<0.05);2组AFC比较,差异无统计学意义(P>0.05)。结论:滋水清肝饮联合西药治疗肾虚肝郁型POF可有效改善患者的中医证候和卵巢功能。

Clinical Study on Zishui Qinggan Yin Combined with Western Medicine for Premature Ovarian Failure of Kidney Deficiency and Liver Stagnation Type

Objective:To observe the clinical effect of Zishui Qinggan yin combined with western medicine for premature ovarian failure(POF) of kidney deficiency and liver stagnation type,and its effect on anti-mullerian hormone(AMH),inhibin B(INHB) and antral follicle count(AFC) in serum of patients. Methods: A total of 86 cases of patients with POF of kidney deficiency and liver stagnation type were selected and divided into the control group and the observation group according to the random number table method,43 cases in each group. The control group was treated with estradiol valerate tablets and progesterone capsules,and the observation group was additionally given Zishui Qinggan yin based on the treatment of the control group. Both groups were treated for one month. Chinese medicine syndrome scores, clinical effect, the levels of AMH and INHB,and AFC values in the two groups were compared. Results:Compared with those before treatment,the menstrual cycle,menstrual blood volume,menstrual color and Chinese medicine syndrome scores in the two groups after treatment were obviously decreased,and the decrease of the above indexes in the observation group was more obvious than that in the control group,the differences being significant(P<0.05). The total effective rate was 95.35% in the observation group,higher than that of 76.74% in the control group,the difference being significant(P<0.05). After treatment,the levels of AMH and INHB and AFC values in the two groups were all increased when compared with those before treatment(P<0.05), and the levels of AMH and INHB in the observation group were higher than those in the control group(P<0.05);compared the AFC values in the two groups,there was no significance in the difference(P>0.05). Conclusion:The therapy of Zishui Qinggan yin combined with western medicine for POF of kidney deficiency and liver stagnation type can effectively improve the Chinese medicine syndromes and ovarian function of patients.