Long-term survival of a patient with small cell lung cancer associated with cancer-associated retinopathy |
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Authors: | Kobayashi Makoto Ikezoe Takayuki Uemura Yoshiki Ueno Hisayuki Taguchi Hirokuni |
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Affiliation: | Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan. kmakoto@kochi-u.ac.jp |
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Abstract: | Cancer-associated retinopathy (CAR) is a rare paraneoplastic disorder that is frequently found in patients with small cell lung cancer (SCLC); it is caused by autoantibody to the 23-kDa photoreceptor protein, recoverin. We report a 9-year survivor of SCLC after concurrent chemoradiotherapy. His anti-recoverin antibody remains positive. Long-term survival without SCLC recurrence might be related to an autoimmunity mechanism that causes CAR due to the presence of anti-recoverin antibody cross-reacting with retinal cells and tumor cells. The current literature review was conducted to evaluate the impact on overall survival according to anti-recoverin antibody status. |
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