Chelation of synaptic zinc induces overexcitation in the hilar mossy cells of the rat hippocampus |
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Authors: | Blasco-Ibáñez José-Miguel Poza-Aznar Julio Crespo Carlos Marqués-Marí Ana-Isabel Gracia-Llanes Francisco-Javier Martínez-Guijarro Francisco-José |
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Institution: | Departamento de Biología Celular, Unidad de Neurobiología, Facultad de Ciencias Biológicas, Universidad de Valencia, Str. Dr Moliner 50, E-46.100 Burjasot, Spain. jose.m.blasco@uv.es |
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Abstract: | Complete removal of synaptic zinc by the chelator dietyldithiocarbamate (DEDTC; 500 mg/kg i.p.) in rat was followed by convulsive behaviour including wet dog shakes alternating immobility. Histological analysis 1 day after DEDTC administration detected expression of heat shock protein in the hippocampus restricted to hilar cells. These cells colocalize the marker for neurons and the glutamate receptor GluR2/3 showing that they are excitatory neurons. Additionally, they projected to the contralateral dentate gyrus. Therefore, they correspond to hilar mossy cells. These data show that the synaptic zinc has a role in normal hippocampus avoiding overexcitation, that would impair functionality even in absence of pathological or exoexcitotoxic phenomena. |
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