| 5-取代苯基-3-吡唑烷酮衍生物的合成及抗癫痫作用研究 |
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| 引用本文： | 李福男,全哲山,朴虎日,宋成岩.5-取代苯基-3-吡唑烷酮衍生物的合成及抗癫痫作用研究[J].中国现代应用药学,2004,21(2):98-100. |
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| 作者姓名： | 李福男 全哲山 朴虎日 宋成岩 |
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| 作者单位： | 延边大学药学院,吉林,延吉,133000 |
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| 摘 要： | 目的寻找具有抗癫痫作用的化合物.方法以取代苯甲醛为起始原料经缩合、酯化、环合及酰化得目标化合物,对所得化合物采用最大电惊厥法测定其抗癫痫活性.结果合成了7个未见文献报道的5-取代苯基-3-吡唑烷酮衍生物.结论初步药理实验表明,化合物4c、4e显示出较强的抗癫痫活性.
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| 关 键 词： | 3-吡唑烷酮 抗癫痫作用 合成 |
| 文章编号： | 1007-7693(2004)02-0098-03 |
Synthesis and antiepileptic activities of 5-Substitued phenyl-3-pyrazolidinoses |
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| LI Fu-nan,QUAN Zhe-shan,PIAO Hu-ri,SONG Cheng-yan.Synthesis and antiepileptic activities of 5-Substitued phenyl-3-pyrazolidinoses[J].The Chinese Journal of Modern Applied Pharmacy,2004,21(2):98-100. |
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| Authors: | LI Fu-nan QUAN Zhe-shan PIAO Hu-ri SONG Cheng-yan |
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| Abstract: | OBJECTIVE To search compounds which have antiepileptic activity. METHOD These objective compounds were synthesized through condensation, esterification, ring closure and acylation steps using benzaldehyde as a starting material. Antiepileptic activities of these compounds were measured with the convulsive method of maximal electricity.RESULTS Seven new derivants of 5-substituted phenyl-3-pyrazo- lidinoses were synthesized. CONCLUSION The results of the pharmacological tests showed that compounds 4c,4e have appreciable antiepileptic activity. |
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| Keywords: | pyrazolidinones antiepileptic activity synthesis |
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