| 香加皮水提物抑制诱导红白血病细胞K562分化的初步研究 |
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| 引用本文： | 李俊新,单保恩. 香加皮水提物抑制诱导红白血病细胞K562分化的初步研究[J]. 癌变．畸变．突变, 2008, 20(6): 449-450. DOI: 10.3969/j.issn.1004-616x.2008.06.008 |
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| 作者姓名： | 李俊新 单保恩 |
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| 作者单位： | 1.青岛市妇女儿童医疗保健中心检验科，山东 青岛 266000;2.河北医科大学第四医院 |
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| 摘 要： | 背景与目的： 研究中药香加皮水提取物(cortex periplocae extract，CPE) 诱导体外培养人红白血病细胞株K562分化的作用。 材料与方法： 观察人红白血病细胞株K562与CPE体外共培养时的形态学变化；同时采用比色法检测不同浓度CPE诱导人红白血病细胞株K562产生Hb含量的变化。 结果： 与阴性对照相比，CPE可以诱导K562细胞发生坏死的形态学变化。与CPE共培养后K562细胞株Hb的产生明显减少。 结论： CPE 对K562肿瘤细胞只具有杀伤作用而不能诱导K562肿瘤细胞的分化。
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| 关 键 词： | 香加皮 K562 杀伤 分化 |
| 收稿时间： | 2007-11-21 |
| 修稿时间： | 2008-06-05 |
The Study of Cortex Periplocae Extract on the Differentiation of K562 Cells |
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| LI Jun-xin,SHAN Bao-en. The Study of Cortex Periplocae Extract on the Differentiation of K562 Cells[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2008, 20(6): 449-450. DOI: 10.3969/j.issn.1004-616x.2008.06.008 |
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| Authors: | LI Jun-xin SHAN Bao-en |
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| Affiliation: | 1. Women and Children's Medical Center, Qingdao 266000，Shandong； 2. Science and Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China |
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| Abstract: | BACKGROUND AND AIM:To investigate the effect of cortex periplocae extract(CPE) on the differentiation of tumor cells K562 in vitro.MATERIALS AND METHODS:We examined the morphological changes of K562 cells after cultured with CPE;and investigated the induction effect of CPE on the production of Hb from K562 cells by using colorimetry.RESULTS:K562 cells morphology were destroyed by CPE.CPE also markedly reduced the production of Hb from K562 cells.CONCLUSION:CPE could kill K562 cells to some extent,but could not induce the differentiation of K562 cells. |
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| Keywords: | K562 |
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