苦楝皮的化学成分

目的对中药苦楝皮(Melia azedarachL.Sied.)体积分数为95%的乙醇提取物的乙酸乙酯部位化学成分进行研究。方法采用硅胶柱色谱、Sephadex LH-20柱色谱等方法进行分离,利用理化性质和1H-NMR1、3C-NMR等谱学技术,对分离得到的化合物进行结构鉴定。结果从中分离得到6个化合物,其结构鉴定为羽扇豆醇(lupeol,1)、α-菠甾酮(-αspinasterone,2)、丁香树脂酚双葡萄糖苷(syringaresinol-di-O--βD-glucoside,3)、阿魏酸(ferulic acid,4)、β-谷甾醇(-βsitosterol,5)、胡萝卜苷(daucosterol,6)。结论化合物2、3和4均为首次从楝属植物中分离得到的已知化合物。

The chemical constituents from Cortex Meliae

Objective To isolate and identify the compounds which were extracted by ethyl acetate from 95％ ethanol extract of Melia azedarach L. ．Method Compounds were isolated by the silica gel and Sephadex LH-20 columns and their structures were identified by the physicochemical properties and the spectral analysis．Result six compounds were obtained and identified as lupeol (1), α-spinasterone (2), syringaresinol-di-O-β-D-glucoside (3), ferulic acid (4), β-sitosterol (5), daucosterol (6). Conclusion Compounds 2, 3 and 4 are obtained from Melia genus for the first time．